Ashwagandha KSM-66

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Goal

Assess how Ashwagandha KSM-66 affects stress level and recovery

Hypothesis

Ashwagandha KSM-66 600mg/day → lower cortisol → less stress → better HRV

KSM-66 is the most well-studied ashwagandha extract. Meta-analyses show an 11-32% reduction in cortisol (Salve 2019, Lopresti 2019)

Expected Effects

  • stress_level
  • hrv_night_avg

Phases

1

Baseline

7 days
  • Live as usual, without adaptogens
  • Rate your stress level in the evening
2

Ashwagandha Intake

21 days
  • Take 300mg KSM-66 in the morning and 300mg in the evening (with food)
  • Take it daily, don't skip
  • Rate your stress level in the evening

Tracked Metrics

Primary

  • stress_level
  • hrv_night_avg

Secondary

Evaluation

Method: compare_phase_means

Design: baseline (7 days) → intervention (21 days)

Safety

Disclaimers

  • Don't combine with sedative medications
  • Contraindicated with hyperthyroidism (ashwagandha stimulates the thyroid)
  • Do not take during pregnancy
  • If taking immunosuppressants, consult a doctor

Stop Conditions

  • GI upset (nausea, diarrhea) lasting more than 3 days
  • Drowsiness that interferes with work
  • Thyrotoxicosis: tremor, rapid heartbeat, weight loss
  • Allergic reaction